The 4th PhUSE SDE Netherlands focuses the attention on the unsung heroes of clinical research and healthcare: data processing solutions. This landscape has never been more turbulent than today and the choice of solutions is greater than ever. This poses many questions. Off-the-shelf or bespoke? All-in-one or smaller modules? Global vendor or local startup? That is not even considering the challenges that arise integrating solutions for data streams, such as EDC, wearables, mobile technology, e-diaries, imaging devices and many others into a single computing environment, where it can be structured and analysed. Should we adopt new data analysis tools and, if so, how do we combine these with existing packages technically and procedurally?